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Telomere Research

The Telomere Science Library is a collection of news articles, medical journal abstracts (and links) and information about telomeres and telomerase.

Early Hits and Long-Term Consequences: Tracking the Lasting Impact of Prenatal Smoke Exposure on Telomere Length in Children

2013 August 8, Tulane University School of Medicine, New Orleans. Katherine P. Theall, PhD, Sarah McKasson, MPH, Emily Mabile, MPH, Lauren F. Dunaway, MPH, and Stacy S. Drury, MD, PhD

Longer Leukocyte Telomeres Are Associated with Ultra-Endurance Exercise Independent of Cardiovascular Risk Factors

2013 July 31, LEW Carty Charitable Fund, the National Health and Medical Research Council of Australia to FJC. Joshua Denham, Christopher P. Nelson, Brendan J. O’Brien, Scott A. Nankervis, Matthew Denniff, Jack T. Harvey, Francine Z. Marques, Veryan Codd, Ewa Zukowska-Szczechowska, Nilesh J. Samani, Maciej Tomaszewski, Fadi J. Charchar

Premature Cell Senescence and T Cell Receptor–Independent Activation of CD8+ T Cells in Juvenile Idiopathic Arthritis

2013 Jul 26, American College of Rheumatology. Jeffrey A. Dvergsten, Robert G. Mueller, Patricia Griffin, Sameem Abedin, Allyson Pishko,Joshua J. Michel,Margalit E. Rosenkranz,Ann M. Reed,Daniel A. Kietz, Abbe N. Vallejo

Posttraumatic Stress Disorder and Not Depression Is Associated with Shorter Leukocyte Telomere Length: Findings from 3,000 Participants in the Population-Based KORA F4 Study

July 3, 2013, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany and the German Federal Ministry of Education and Research (BMBF), Berlin, Germany. Karl-Heinz Ladwig, Anne Catharina Brockhaus, Jens Baumert, Karoline Lukaschek, Rebecca T. Emeny, Johannes Kruse, Veryan Codd, Sibylle Häfner, Eva Albrecht, Thomas Illig, Nilesh J. Samani, H. Erich Wichmann, Christian Gieger, Annette Peters

The antiretroviral agent saquinavir enhances hTERT expression and telomerase activity in human T leukaemia cells in vitro

8 June 2013, BioMed Central Ltd. Riccardo Adamo, Alessandro Comandini, Angelo Aquino, Laura Bonmassar, Loredana Guglielmi, Enzo Bonmassar, Ornella Franzese

Telomere length influences cancer cell differentiation in vivo

28 May 2013, Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research. Kyotaro Hirashima, Toshiro Migita, Shigeo Sato, Yukiko Muramatsu, Yuichi Ishikawa and Hiroyuki Seimiya

Functional Assessment of Pharmacological Telomerase Activators in Human T Cells

2013 Jan 14, Department of Biology, Whittier College, CA, USA; Department of Pathology and Lab Medicine, David Geffen School of Medicine at UCLA, la, CA, USA. Brenda Molgora, Riley Bateman, Greg Sweeney, Danielle Finger, Taylor Dimler, Rita B. Effros and Hector F. Valenzuela

Telomere length and its relationship with chronic diseases – New perspectives for periodontal research.

2012 Nov 29, Department of Physiology and Pathology, São Paulo State University, School of Dentistry at Araraquara, Araraquara, SP, Brazil. Steffens JP, Masi S, D’Aiuto F, Spolidorio LC

Long telomeres in blood leukocytes are associated with a high risk of ascending aortic aneurysm.

2012 Nov 29, Huusko TJ, Santaniemi M, Kakko S, Taskinen P, Ukkola O, Kesäniemi YA, Savolainen MJ, Salonurmi T

Beyond average: potential for measurement of short telomeres.

Aging (Albany NY). 2012 Jun 8. Vera E, Blasco MA.

CNIO scientists successfully test the first gene therapy against aging-associated decline

14-May-2012 Centro Nacional de Investigaciones Oncologicas (CNIO)

Shorter telomere length is associated with increased ovarian cancer risk in both familial and sporadic cases.

J Med Genet. 2012 May;49(5):341-4. Epub 2012 Apr 6. Martinez-Delgado B et al

The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder.

J Affect Disord. 2011 Dec;135(1-3):43-50. Epub 2011 Aug 30. Elvsåshagen T et al

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence.

Aging Cell. 2011 Aug;10(4):604-21. doi: 10.1111/j.1474-9726.2011.00700. Blasco MA et al

Biologic function and clinical potential of telomerase and associated proteins in cardiovascular tissue repair and regeneration.

Eur Heart J. 2011 May;32(10):1190-6. Madonna R et al A natural product telomerase activator as part of a health maintenance program.Rejuvenation Res. 2011 Feb;14(1):45-56. Harley CB et al

María Blasco: Keeping a cap on cancer and aging

Interview by Caitlin Sedwick. J Cell Biol. 2011 Feb 7;192(3):370-1 Blasco M.

Telomeres in cancer and aging.

Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):76-84. Donate LE, Blasco MA.

Aging by telomere loss can be reversed.

Cell Stem Cell. 2011 Jan 7;8(1):3-4. Bernardes de Jesus B, Blasco MA.

The role of telomeres and telomerase in stem cell aging.

FEBS Lett. 2010 Sep 10;584(17): 3826-30. Flores I, Blasco MA.

Telomere shortening and aging of the immune system.

J Physiol Pharmacol. 2008 Dec;59 Suppl 9:169-86. Kaszubowska L.

Telomerase deficiency promotes oxidative stress by reducing catalase activity.

Free Radic Biol Med. 2008 Nov 1;45(9):1243-51. Epub 2008 Jul 30. Pérez-Rivero G et al

Telomeres and aging

Physiol Rev. 2008 Apr;88(2):557-79. Aubert G, Lansdorp PM.

Telomerase induction in T cells: a cure for aging and disease?

Exp Gerontol. 2007 May;42(5):416-20. Epub 2006 Dec 19.

Short Sleep Duration Is Associated with Shorter Telomere Length in Healthy Men: Findings from the Whitehall II Cohort Study

PLoS ONE 7(10): e47292. doi:10.1371/journal.pone.0047292 October 29, 2012. Marta Jackowska mail, Mark Hamer, Livia A. Carvalho, Jorge D. Erusalimsky, Lee Butcher, Andrew Steptoe

UCSF-led study suggests link between psychological stress and cell aging

UCSF, November 29, 2004

Work-Related Exhaustion and Telomere Length: A Population-Based Study

Ahola K, Sirén I, Kivimäki M, Ripatti S, Aromaa A, et al. (2012) Work-Related Exhaustion and Telomere Length: A Population-Based Study. PLoS ONE 7(7): e40186. doi:10.1371/journal.pone.0040186, July 11, 2012

Telomere length and early severe social deprivation: linking early adversity and cellular aging

Molecular Psychiatry 17, 719-727 (July 2012) | doi:10.1038/mp.2011.53, S S Drury, K Theall, M M Gleason, A T Smyke, I De Vivo, J Y Y Wong, N A Fox, C H Zeanah and C A Nelson

Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood

June 3, 2011, Sonja Entringer, Elissa S. Epel, Robert Kumsta, Jue Lin, Dirk H. Hellhammer, Elizabeth H. Blackburn, Stefan Wüst, and Pathik D. Wadhw

Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA)

2008 American Society for Clinical Nutrition, Jennifer A Nettleton, Ana Diez-Roux, Nancy S Jenny, Annette L Fitzpatrick, and David R Jacobs Jr

Wandering Minds and Aging Cells

Elissa S. Epel, Eli Puterman, Jue Lin, Elizabeth Blackburn, Alanie Lazaro, Wendy Berry Mendes

The Association between Intelligence and Telomere Length: A Longitudinal Population Based Study

Kingma EM, de Jonge P, van der Harst P, Ormel J, Rosmalen JGM (2012)

Longevity genes challenged

Telomere Length Correlates with Life Span of Dog Breeds

Cell Reports, Volume 2, Issue 6, 1530-1536, 20 December 2012, Laura J. Fick, Gordon H. Fick, Zichen Li, Eric Cao, Bo Bao, Doug Heffelfinger, Heidi G. Parker, Elaine A. Ostrander, Karl Riabowol

Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women.

Brain Behav Immun. 2009 May;23(4):446-9. doi: 10.1016/j.bbi.2008.11.006. Epub 2008 Dec 11., O’Donovan A, Lin J, Tillie J, Dhabhar FS, Wolkowitz OM, Blackburn EH, Epel ES.

Association of Longer Telomeres With Better Health in Centenarians

Oxford Journals, Medicine & Social Sciences, The Journals of Gerontology: Series A, Volume 63, Issue 8, Pp. 809-812. Dellara F. Terry, Vikki G. Nolan, Stacy L. Andersen, Thomas T. Perls and Richard Cawthon

Short Telomere Length, Myocardial Infarction, Ischemic Heart Disease, and Early Death

Maren Weischer, Stig E. Bojesen, Richard M. Cawthon, Jacob J. Freiberg, Anne Tybjærg-Hansen, Børge G. Nordestgaard

Abstract 1380: Beneficial Effects of Long-term Endurance Exercise on Leukocyte Telomere Biology

(Circulation. 2009;120:S492.) © 2009 American Heart Association, Inc.

Start Active, Stay Active.A report on physical activity for health from the four home countries’ Chief Medical Ofcers

Effect of parental age at birth on the accumulation of deficits, frailty and survival in older adults

Oxford Journals, Medicine, Age and Ageing, Volume 38, Issue 4 Pp. 380-385. Ruth E. Hubbard, Melissa K. Andrew and Kenneth Rockwood

Delayed paternal age of reproduction in humans is associated with longer telomeres across two generations of descendants

Increased telomerase activity and comprehensive lifestyle changes: a pilot study.

Lancet Oncol. 2008 Nov; Ornish D, Lin J, Daubenmier J, Weidner G, Epel E, Kemp C, Magbanua MJ, Marlin R, Yglecias L, Carroll PR, Blackburn EH.

Intensive meditation training, immune cell telomerase activity, and psychological mediators

Psychoneuroendocrinology Volume 36, Issue 5, June 2011, Pages 664–681

A common polymorphism near PER1 and the timing of human behavioral rhythms

2012 American Neurological Association

Work-Related Exhaustion and Telomere Length: A Population-Based Study

PLoS ONE 7(7): e40186. doi:10.1371/journal.pone.0040186 July 11, 2012; Ahola K, Sirén I, Kivimäki M, Ripatti S, Aromaa A

Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Increase Health Span and Extend Mouse Longevity

PLoS ONE 8(1): e53760. doi:10.1371/journal.pone.0053760; January 22, 2013; Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA

Association Between Telomere Length and Experimentally Induced Upper Respiratory Viral Infection in Healthy Adults

JAMA. 2013;309(7):699-705. doi:10.1001/jama.2013.613; Sheldon Cohen, PhD; Denise Janicki-Deverts, PhD; Ronald B. Turner, MD; Margaretha L. Casselbrant, PhD, MD; Ha-Sheng Li-Korotky, PhD, MD; Elissa S. Epel, PhD; William J. Doyle, PhD

Older adults with higher income or marriage have longer telomeres

Oxford Journals, Medicine, Age and Ageing, Advance Access, 10.1093/ageing/afs122; Yung-Chieh Yen and For-Wey Lung

Telomere dynamics in a long-lived bird, the barnacle goose

BMC Evolutionary Biology 2012, 12:257 doi:10.1186/1471-2148-12-257 Angela Pauliny, Kjell Larsson and Donald Blomqvist

Perceived age as clinically useful biomarker of ageing: cohort study

BMJ 2009; Kaare Christensen, Mikael Thinggaard, Matt McGue, Helle Rexbye, Jacob v B Hjelmborg, Abraham Aviv, David Gunn, Frans van der Ouderaa and James W Vaupel

The analysis of four commonly available commercial products for the presence of TA-65

2007 May 23, Dalton Pharma Services